High density lipoprotein - 3 in diabetic retinopathy patients: relationship to total antioxidant capacity and nitric oxide level / 国际眼科杂志(Guoji Yanke Zazhi)

·AIM: To examine the association between high density lipoprotein ( HDL) 3 cholesterol, nitrite plus nitrate ( NOx) and total antioxidant status in diabetic retinopathy patients compared to controls.·METHODS:This was a prospective, case-control study. One hundred and six participants were subdivided into three groups. Eighty-four type 2 diabetes patients with and without retinopathy and 22 healthy controls were included in this study. Serum HDL3 concentrations were assayed and serum NOx levels were determined in all patients. Total antioxidant capacity was measured using the ferric reducing power of plasma ( FRAP) assay.·RESULTS: Among the subjects with diabetes mellitus (DM), fasting glucose, HbA1c and triglycerides were significantly higher than the healthy controls. HDL3 level was 14. 4 ( 12. 0 ) mg/dl in healthy subjects, 18. 1 ( 12. 6 ) mg/dl in the diabetic retinopathy group and 14. 0 (12. 5) mg/dl in diabetic patients without retinopathy, and was statistically similar between the groups (P=0. 262). HDL level was similar between groups in our population. FRAP level was lower in patients with DM compared to healthy controls (P=0. 003), but was not different between the DR and the non-DR groups (P=0. 913).·CONCLUSION:In our study, we demonstrated that HDL and HDL3 subgroup levels didn't significantly differ between DM2 patients with DR and without DR and healthy controls. Determination of HDL3 cholesterol, in addition to total HDL cholesterol, may not predict the actual risk for diabetic retinopathy. Serum NOx was observed to be higher in diabetic participants and FRAP level was low.

The Cumulative Colectomy Rate in Patients with Cytomegalovirus-Positive Ulcerative Colitis

No abstract available.

Limitations in imaging common conjunctival and corneal pathologies with fourier-domain optical coherence tomography

To describe the limitations of Fourier-domain optical coherence tomography [OCT] in imaging common conjunctival and corneal pathology. Retrospective, single-center case series of 40 patients with conjunctival and cornea pathology. Fourier-domain OCT imaged laser in situ keratomileusis [LASIK] flaps in detail, including its relation to other corneal structures and abnormalities. Similarly, in infectious or degenerative corneal disorders, Fourier-domain OCT successfully showed the extent of infiltration or material deposition, which appeared as hyper-reflective areas. In cases with pterygium, the underlying cornea could not be imaged. All cases of common conjunctival pathologies, such as nevus or pinguecula, were successfully imaged in detail. Nevi, scleritis, pterygium, pinguecula, and subconjunctival hemorrhage were hyper-reflective lesions, while cysts and lymphangiectasia were hyporeflective. The details of the underlying sclera were not uniformly imaged in conjunctival pathologies. Fourier-domain OCT imaged the trabeculectomy bleb in detail, whereas the details of structures of the anterior chamber angle were not routinely visualized in all cases. Light scatter through vascularized, densely inflamed, or thick lesions limits the imaging capabilities of Fourier-domain anterior segment OCT

Eyelid angiosarcoma: a case report and review of the literature

A 77-year-old woman presented with a 3-month history of a lesion on her left lower eyelid. External examination showed a tan-colored nodule with an overlying crust-covered ulcer on the left lower eyelid, nasally. The ulcer measured 12 mmx7 mm. Complete surgical excision with a frozen section margin control was performed. Histopathological examination showed islands and sheets of spindle and epithelioid cells with little intervening stroma. The cells had copious amounts of either rounded or tapered eosinophilic cytoplasm with occasional intracytoplasmic lumina and large vesicular nuclei with prominent nucleoli. There was intense immunoreactivity for CD34, CD31, factor VIII, and Ki-67. The diagnosis was eyelid angiosarcoma. The patient refused any further therapy. At 1-year follow-up, there was no recurrence or development of metastasis. In conclusion, tan-colored eyelid nodules with overlying ulcer are usually a basal cell carcinoma; however, rarely it can be an eyelid angiosarcoma